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    Chirurgische Behandlung von Diabetes. In unserer Klinik wird eine chirurgische Behandlung von Typ-2-Diabetes durchgefГјhrt. Typ 2 Diabetes – Heute ist kein Satz mehr! Typ-2-Diabetes mellitus ist eine Stoffwechselerkrankung (StoffwechselstГ¶rung), die durch chronische HyperglykГ¤mie (erhГ¶hter Blutzucker) gekennzeichnet ist und sich infolge einer Verletzung der Wechselwirkung von Insulin mit Gewebezellen entwickelt. Diese Krankheit hat eine Reihe schwerwiegender Komplikationen: Angiopathie. Erstens leiden bei Diabetes Blutgefäße. Ihre WГ¤nde werden fГјr NГ¤hrstoffe weniger durchlГ¤ssig und das Lumen der Gefäße verengt sich allmГ¤hlich. Allen KГ¶rpergeweben fehlt es an Sauerstoff und anderen lebenswichtigen Substanzen. Nephropathie Die Nieren eines Patienten mit Diabetes mellitus verlieren allmГ¤hlich ihre FГ¤higkeit, ihre Funktionen zu erfГјllen, es entsteht ein chronisches Versagen. Retinopathie – SchГ¤digung der Netzhaut, die dann zu Blutungen im Fundus und AblГ¶sung der Netzhaut fГјhrt. AllmГ¤hlich fГјhrt dies zu einem vollstГ¤ndigen Verlust des SehvermГ¶gens. Die hГ¤ufigste Retinopathie tritt bei Patienten mit Typ-2-Diabetes auf. FГјr einen Patienten mit einer „Erfahrung“ von mehr als 20 Jahren nГ¤hert sich das Risiko einer Retinopathie 100%. Polyneuropathie. Verlust der Empfindlichkeit gegenГјber Schmerzen und Hitze in den GliedmaГџen. Meistens entwickelt es sich nach der Art der „Handschuhe und StrГјmpfe“ und beginnt sich gleichzeitig in den unteren und oberen GliedmaГџen zu manifestieren. Die ersten Symptome sind ein GefГјhl der Taubheit und des Brennens in den GliedmaГџen, die nachts erheblich verstГ¤rkt werden. Diabetischer FuГџ. Eine Komplikation, bei der offene Wunden, eitrige Abszesse, nekrotische (tote) Bereiche an den FГјГџen und unteren ExtremitГ¤ten eines Patienten mit Diabetes mellitus auftreten. In den letzten Jahrzehnten ist die PrГ¤valenz von Diabetes mellitus (DM) zu einer Epidemie geworden: Wenn beispielsweise die Zahl der Diabetes-Patienten Ende des letzten Jahrhunderts weltweit 130 Millionen nicht Гјberstieg, liegt ihre Zahl derzeit bei mehr als 300 Millionen und bis 2030 laut Prognosen Die International Diabetes Association wird um das 1,5-fache zunehmen und 438 Millionen Menschen umfassen, hauptsГ¤chlich aufgrund von Patienten mit Typ-2-Diabetes, die mehr als 90% der Gesamtzahl der Patienten ausmachen. Heutzutage besteht die Tendenz, nicht nur die Inzidenz von Typ-2-Diabetes zu erhГ¶hen, sondern auch die Entwicklung dieser Pathologie in einem jГјngeren Alter, was mit einer VerstГ¤dterung des Territoriums, einer Zunahme der PrГ¤valenz von Fettleibigkeit und einem sitzenden Lebensstil verbunden ist. Mit einer medizinischen Behandlung (Einnahme von zuckersenkenden Medikamenten und in einigen FГ¤llen Insulininjektionen) kann diese Krankheit nicht geheilt werden, weil Diese Therapie ist ein Ersatz. GegenwГ¤rtig ist die chirurgische Methode zur Behandlung dieser Pathologie in der Welt bereits bekannt und ihre enorme Wirksamkeit wurde bewiesen. Die chirurgische Behandlung von Typ-2-Diabetes mellitus ermГ¶glicht es Ihnen, diese Pathologie loszuwerden und die Einnahme von zuckersenkenden Medikamenten vollstГ¤ndig zu unterbinden. Diese chirurgische Richtung gehГ¶rt zum Bereich der Stoffwechselchirurgie. Die metabolische Chirurgie ist eine Methode fГјr chirurgische Eingriffe, die darauf abzielt, die Funktion wiederherzustellen oder die Funktion des Stoffwechselsystems zu normalisieren. Basierend auf klinischen Studien Гјber 10 Jahre erwies sich der effektivste chirurgische Eingriff als – Magenbypass (Mini-Magenbypass) Es stellte sich heraus, dass die DurchfГјhrung solcher Operationen in 2-90% der FГ¤lle zur Heilung von Typ-98-Diabetes fГјhrt. Diese Tatsache diente als Ausgangspunkt fГјr Studien Гјber die MГ¶glichkeit, eine solche Stoffwechseloperation zur radikalen Behandlung von Typ-2-Diabetes bei Patienten nicht nur mit Adipositas, sondern auch mit normalem Gewicht oder bei Vorhandensein eines moderaten Гњbergewichts (mit einem BMI von bis zu 30) einzusetzen. Was ist der Sinn dieser Operation? Der Blutzuckerspiegel normalisiert sich in den ersten Tagen nach der Operation wieder. Innerhalb weniger Jahre erreicht das Gewicht des Patienten zufriedenstellende Werte (bei einem Wachstum von 180 cm betrГ¤gt das ungefГ¤hre Gewicht beispielsweise 80-85 kg). Die Reduzierung des Magenvolumens fГјhrt zu einer schnellen SГ¤ttigung. Die Aufnahme von Nahrung aus dem Magen direkt in das Ileum unter Umgehung der DГјnnen. Der Patient entfernt sich in 98% von Insulininjektionen, in 85% von der Zuckeraufnahme reduzierender Medikamente. Frage – warum bemГјhen wir uns, den Kontakt von Lebensmitteln mit dem Ileum zu beschleunigen? In der Schleimhaut des Ileums befindliche L-Zellen produzieren ein Glucagon-Г¤hnliches Peptid-1. Je kleiner die Nahrung, die in das Ileum gelangt, von den VerdauungssГ¤ften verarbeitet wird, und je frГјher sie in das Ileum gelangt, desto deutlicher wird die Reizung der L-Zellen. Wenn eine L-Zell-Reizung auftritt: Verminderter Appetit. Verminderte Magenentleerung ErhГ¶ht das Wachstum von Zellen, in denen Insulinsynthese stattfindet Insulin erhГ¶hen Reduziert die Apoptose von Beta-Zellen (reduziert das AusmaГџ der “SelbstzerstГ¶rung” von Zellen, die Insulin synthetisieren), verringert die Sekretion von Glucagon. ErhГ¶ht die InsulinsensitivitГ¤t Es fГјhrt zur Aktivierung des Schutzsystems der Herzzellen. Die Methode des chirurgischen Eingriffs ist laparoskopisch! In unserem medizinischen Zentrum wird diese Operation mit modernen minimalinvasiven Techniken durchgefГјhrt. Maximaler Komfort fГјr den Patienten in der frГјhen postoperativen Phase Mindestaufenthalt im Krankenhaus Reduziert das Risiko von Infektionen und postoperativen Problemen Kosmetischer Effekt. Was sind die Indikationen fГјr eine chirurgische Behandlung? Menschen, die in den frГјhen Stadien der Krankheit an Diabetes leiden, beklagen sich nicht und daher ist es nicht einfach, sich fГјr eine Operation zu entscheiden. Eine Operation, auch wenn sie geplant ist, ist immer mit einem bestimmten Risiko verbunden. Ohne 100% aller Indikationen wird unser Zentrum diese Art der Behandlung daher nicht empfehlen. Das Alter des Patienten liegt zwischen 30 und 65 Jahren. Typ 2 Diabetes mellitus nicht lГ¤nger als 10 Jahre, Behandlung mit oralen Medikamenten. Typ-2-Diabetes mellitus nicht lГ¤nger als 10 Jahre, InsulinabhГ¤ngigkeit weniger als 7 Jahre, schwer zu kontrollieren (HbA1c> 8,0%) Patienten mit Diabetes mellitus mit ausreichender Reserve der BauchspeicheldrГјse (C-Peptid> = 1 ng / ml, obligatorischer Glucagon-Test). negativer Test auf AntikГ¶rper gegen Pankreas-ОІ-Zellen (ICA, IA-2, GAD 65 K). Patienten mit einem hohen Body-Mass-Index (BMI> 30 kg / m2), begleitet von Typ-2-Diabetes. Klinische Studien – bringen Sie zum Nachdenken! 85% Das ist eine Menge! Die Magenbypass-Operation hat eine mehr als 50-jГ¤hrige Geschichte. Die positive Wirkung dieser Art von Stoffwechseloperation auf den Verlauf von Diabetes wurde wiederholt durch zahlreiche klinische Studien bestГ¤tigt, in denen die Langzeitergebnisse von Operationen untersucht wurden. Es wurde gezeigt, dass bei 85% der Patienten nach einer Magenbypass-Operation eine vollstГ¤ndige Heilung des Diabetes beobachtet wurde. Diese Patienten konnten jede medikamentГ¶se Therapie vollstГ¤ndig abbrechen. Die verbleibenden 2-15% zeigten eine signifikante positive Dynamik in Form einer Verringerung der Dosierung von Antidiabetika. Eine Studie mit Langzeitergebnissen zeigte, dass die MortalitГ¤t aufgrund von Komplikationen bei Diabetes in der Gruppe, in der eine chirurgische Behandlung durchgefГјhrt wurde, um 92% niedriger war als in der Gruppe, in der eine konservative Behandlung durchgefГјhrt wurde. Es wurden klinische Studien durchgefГјhrt, in denen die Auswirkung einer Stoffwechseloperation auf Typ-2-Diabetes bei Patienten mit normalem KГ¶rpergewicht und moderatem Гњbergewicht (mit einem BMI von bis zu 30) untersucht wurde. Diese Studien haben die positiven Ergebnisse vollstГ¤ndig dupliziert – 90% der Heilung fГјr Typ-2-Diabetes in dieser Kategorie von Patienten und positive Dynamik in den verbleibenden 10%. Wenn der Body-Mass-Index eines Patienten mit Diabetes 35 oder hГ¶her betrГ¤gt, gilt die Operation als unbedingt angezeigt. Wenn Patienten mit normalem oder mäßig erhГ¶htem KГ¶rpergewicht betroffen sind, mГјssen gleichzeitig die Risiken einer Operation und die potenziellen positiven Auswirkungen einer Heilung von Diabetes bewertet werden. In Anbetracht der Tatsache, dass selbst die DurchfГјhrung einer kompetenten konservativen Therapie keine zuverlГ¤ssige PrГ¤vention von Diabetes-Komplikationen darstellt (diabetische Retinopathie, Nephropathie, Neuropathie und Angiopathie mit dem gesamten Spektrum ihrer schwerwiegenden Folgen), kann sich die Anwendung der Stoffwechselchirurgie selbst bei dieser Gruppe von Patienten mit Typ-2-Diabetes als vielversprechende Behandlungsmethode herausstellen . Derzeit wird angenommen, dass eine Operation fГјr einen Patienten mit Typ-2-Diabetes bei einem BMI von weniger als 35 angezeigt ist, wenn er mit oralen Medikamenten keine EntschГ¤digung fГјr den Krankheitsverlauf erzielen kann und Sie auf die Ernennung von Insulin zurГјckgreifen mГјssen. Da der Hauptmechanismus der Krankheit bei einem Patienten mit Typ-2-Diabetes mellitus die Insulinresistenz und nicht der Insulinmangel ist, scheint diese Ernennung von zusГ¤tzlichem exogenem Insulin eine streng obligatorische MaГџnahme zu sein, die nicht auf die Ursache der Krankheit abzielt. Andererseits fГјhrt die Operation zur Beseitigung der Insulinresistenz gleichzeitig mit der Normalisierung des GlykГ¤mieniveaus. Die dritte Gruppe von Indikationen ist die Bypass-Operation bei Patienten mit Diabetes mellitus mit einem BMI von 23-35, die kein Insulin erhalten. Diese Patientengruppe ist derzeit eine Forschungsgruppe. Es gibt Patienten mit normalem oder leicht erhГ¶htem Gewicht, die das Problem ihres Diabetes radikal lГ¶sen wollen. Sie sind in solchen Studien enthalten. Die Ergebnisse sind sehr ermutigend – eine stabile klinische und labortechnische Remission von Diabetes in dieser Gruppe wird bei allen Patienten erreicht. Um zu verhindern, dass Diabetes mellitus in eine komplexe Form Гјbergeht, die eine konstante Insulinaufnahme erfordert, muss gelernt werden, wie man die Krankheit kontrolliert. Das neueste Medikament Insumed trГ¤gt dazu bei , das hilft, Diabetes „auf zellulГ¤rer Ebene“ loszuwerden: Das Medikament stellt die Insulinproduktion wieder her (die bei Typ-2Diabetes beeintrГ¤chtigt ist) und reguliert die Synthese dieses Hormons (wichtig ist das fГјr Typ-1Diabetes ). Alle Bestandteile der Zubereitung werden auf der Basis von Pflanzenmaterialien unter Verwendung der Biosynthesetechnik hergestellt und sind mit dem menschlichen KГ¶rper verwandt. 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